Thong Luong (MED '22) Advisor Kara Bernstein, PhD Dissertation Role and regulation of yeast Hrq1 and its human homolog, RECQL4, during DNA crosslink repair (2022) Atinuke Dosunmu-Ogunbi (MED '21) Advisor Adam C. Straub, PhD Dissertation The Role of Superoxide Dismutase 2 in Modulating Sickle Cell Disease Pathology (2021) Nicholas Todd (MED '21) Advisor Amantha Thathiah, PhD Dissertation The role of G protein-coupled receptor kinases in modulating ?-secretase activity and amyloid-ß generation (2021) Joseph Galley (MED '21) Advisor Adam C. Straub, PhD Dissertation Mechanisms of Guanylyl Cyclase Gene Regulation by FoxO Transcription Factors (2021) Lloyd Harvey (MED '21) Advisor Stephen Chan, MD, PhD Dissertation NCOA7 Deficiency Reprograms Lysosomal Behavior and Sterol Metabolism to Promote Endothelial Dysfunction and Pulmonary Arterial Hypertension (2021) Anastasia Gorelova (MED '20) Advisor Imad Al Ghouleh, PhD Dissertation The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension (2020) Zheqi Li (MED '20) Advisor Steffi Oesterreich, PhD Dissertation Hotspot Mutations on Estrogen Receptor-a Are Multimodal and Contextual Drivers of Breast Cancer Endocrine Resistance and Metastasis (2020) Braulio Bonilla (MED '20) Advisor Kara A. Bernstein, PhD Dissertation The budding yeast Shu complex promotes the error-free bypass of abasic sites and 3-methylcytosines (2020) Gregory Buchan (MED '19) Advisor Bruce A. Freeman, PhD Dissertation Formation and signaling of electrophilic lipids in immunity (2019) Song-My Hoang (MED '19) Advisor Roderick J. O'Sullivan, PhD Dissertation Control of telomeric homology-directed repair by poly(ADP-ribose) metabolism (2019) Ravi Patel (MED '19) Advisor Thomas E. Smithgall, PhD Dissertation SRC-FAMILY KINASES IMPACT PROGNOSIS AND TARGETED THERAPY IN FLT3-ITD+ ACUTE MYELOID LEUKEMIA (2019) Nolan Carew (MED '19) Advisor Adam C. Straub, PhD Joshua Lorenz - Guertin (MED '19) Advisor Tija C. Jacob, PhD Dissertation REGULATION OF GABAAR SIGNALING AND NEUROADAPTATIONS IN RESPONSE TO DIAZEPAM. (2019) Alparslan Asan (MED '19) Advisor Carola Neumann, MD Dissertation Nitroalkene Repression of Homologous Recombination as a Treatment for Triple Negative Breast Cancer (2019) Shireen Attaran (MED '18) Advisor Carola Neumann, MD Dissertation INVESTIGATING THE INFLUENCE OF OXIDATIVE STRESS AND THE ROLE OF PRDX1 IN THE REGULATION OF LYSYL OXIDASE MEDIATED ECM AND COLLAGEN REMODELING IN BREAST CANCER METASTASIS Emily Bossart (MED '18) Advisor Steffi Oesterreich, PhD Dissertation Investigation of EMT-like Phenotypes in Established and Novel Model Systems of Invasive Lobular Breast Carcinoma Rochelle Fletcher (MED '18) Advisor Lin Zhang, PhD Dissertation The Role of NSAID-Induced ER Stress and Immunomodulation in the Suppression of Colorectal Tumorigenesis Soma Jobbagy (MED '18) Advisor Francisco J. Schopfer, PhD Dissertation Impact of Nrf2 signaling on thiol homeostasis and renal physiology Eleanor Johnston (MED '18) Advisor Christopher Bakkenist, PhD Alison Nagle (MED '18) Advisor Adrian Lee, PhD Dissertation Credentialing IGF1R pathway activation as a novel therapeutic target in E-cadherin deficient breast cancer Nyla Naim (MED '18) Advisor Daniel Altschuler, PhD Dissertation LUMINESCENCE-ACTIVATED CYCLASE ALLOWS LOCALIZED PHOTO AND CHEMICAL STIMULATION OF cAMP SYNTHESIS (2018) Vera Procaccia (MED '18) Advisor Dr. Alessandro Bisello Dissertation THE SCAFFOLDING PROTEIN EBP50 REGULATES MITOCHONDRIAL DYNAMICS AND REDOX BALANCE IN VASCULAR SMOOTH MUSCLE CELLS Nicholas Smith (MED '18) Advisor Adrian Lee, PhD Zachary Yochum (MED '18) Advisor Timothy F. Burns, MD, PhD Dissertation TWIST1 Suppresses Apoptosis and Mediates Therapeutic Resistance in Non-Small Cell Lung Cancer Nolan Priedigkeit (MED '17) Advisor Adrian Lee, PhD Dissertation Identification of acquired molecular dependencies in advanced breast and ovarian cancers Chen-Shan (Julia) Woodcock (MED '17) Advisor Bruce A. Freeman, PhD Dissertation Therapeutic Potential of Electrophilic Nitro-Oleic Acid for The Treatment of Triple-Negative Breast Cancer Courtney Andersen (MED '16) Advisor Steffi Oesterreich, PhD Dissertation TARGETING ESTROGEN RECEPTOR AS A STRATEGY FOR PERSONALIZED MEDICINE IN OVARIAN CANCER Christopher Barnes (MED '16) Advisor Guillermo A. Calero, MD Dissertation MECHANISTIC INSIGHTS INTO EUKARYOTIC TRANSCRIPTION USING NOVEL CRYSTALLOGRAPHIC TECHNIQUES Kenneth Drombosky (MED '16) Advisor Ronald B. Wetzel, PhD Dissertation HUNTINGTON’S DISEASE STUDIES AT THE INTERFACE OF CHEMISTRY, PHYSICS, AND BIOLOGY (2016) Kyle Knickelbein (MED '16) Advisor Lin Zhang, PhD Dissertation Mechanisms and Novel Therapeutic Approaches for KRAS-Mediated Resistance to Anti-EGFR Therapy in Colorectal Cancer Cells (2016) Mark Weir (MED '16) Advisor Thomas E. Smithgall, PhD Dissertation SIMULTANEOUS INHIBITION OF DRIVER AND EFFECTOR KINASES PROMOTES POTENT GROWTH ARREST OF AML CELLS IN VITRO AND IN VIVO Andrea Braganza (MED '15) Advisor Robert W. Sobol, PhD Dissertation UBE3B is a mitochondria-associated E3 ubiquitin ligase whose activity is modulated by its interaction with Calmodulin to respond to oxidative stress Matthew Hedberg (MED '15) Advisor Jennifer Grandis, MD Dissertation Leveraging Next Generation Sequencing to Elucidate the Spectrum of Genetic Alterations Underlying Head and Neck Cancer and Identify Potential Therapeutic Targets David Osei-Hwedieh (MED '15) Advisor Mark T. Gladwin, MD Dissertation THE EFFECT OF SICKLE HEMOGLOBIN MUTATION ON RED BLOOD CELL STORAGE INTEGRITY AND POST TRANSFUSION VIABILITY Noah Peyser (MED '15) Advisor Jennifer Grandis, MD Dissertation PTPRT/D MUTATION OR PROMOTER METHYLATION: IMPLICATIONS FOR STAT3 INHIBITION Atif Towheed (MED '15) Advisor Michael J. Palladino, PhD Dissertation Allotopic RNA expression strategy to rescue an endogenous mitochondrial ATP6[1] mutation in Drosophila Anny Treat (Caceres) (MED '15) Advisor Guillermo G. Romero, PhD Dissertation THE ROLE OF NHERF1/EBP50 IN WNT SIGNALING IN THE EPITHELIUM Wai Kan (Karen) Chiu (MED '14) Advisor Michael J. Palladino, PhD Dissertation Mitochondrial Allotopic Gene Therapy Approaches Using a Drosophila Model with an Endogenous ATP6 Mutation Andrey Finegersh (MED '14) Advisor Gregg E. Homanics, PhD Dissertation Epigenetic Effects of Ethanol Anne Lipton Keener (MED '14) Advisor Zhou Wang, PhD Dissertation EAF2 Associates with FOXA1 and EAF2 Alleviates FOXA1-Mediated Repression of Androgen Receptor Transactivation Daniel Ranayhossaini (MED '14) Advisor Patrick J. Pagano, PhD Dissertation Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition Bartholomew Roland (MED '14) Advisor Michael J. Palladino, PhD Dissertation An in vivo structure-function analysis of the pathogenesis of triosephosphate isomerase deficiency Hilary Stevenson (MED '14) Advisor Guillermo A. Calero, MD Dissertation USE OF TRANSMISSION ELECTRON MICROSCOPY TO IDENTIFY NANOCRYSTALS OF CHALLENGING PROTEIN TARGETS Rekha Gyanchandani (MED '13) Advisor Seungwon Kim, MD Dissertation Molecular Determinants of Response to Antiangiogenic Therapies in Preclinical Models of Head and Neck Squamous Cell Carcinoma Kristen Leslie (Balogh) (MED '13) Advisor Dr. Alessandro Bisello Dissertation Exploring the Role of EBP50 in Vascular Inflammation Jamie Moroco (MED '13) Advisor Thomas E. Smithgall, PhD Mitchell Springer (MED '13) Advisor John P. Horn, PhD Dissertation Modulation of Synaptic Amplification in Sympathetic Ganglia Mark Zimmerman (MED '13) Advisor Gregg E. Homanics, PhD Dissertation Targeted Deletion of Ptp4a3 Inhibits Colon Carcinogenesis and Angiogenesis Cassandra Henry (MED '12) Advisor Jill M. Siegfried, PhD Jeffrey Koenitzer (MED '12) Advisor Bruce A. Freeman, PhD Dissertation Electrophillic Nitro-Fatty Acid Regulation of Mitochondrial Function Callie A Norris (MED '12) Advisor Elias Aizenman, PhD Shoghag B Panjarian (MED '12) Advisor Thomas E. Smithgall, PhD Dissertation Investigating Allosteric Regulation of ABL and BCR-ABL Kinases: Implications for Small Molecule Inhibitors Kelly Quesnelle (MED '12) Advisor Jennifer Grandis, MD Dissertation Intracellular Signaling Mechanisms of Resistance to TGFR-Targeting Agents David Svilar (MED '12) Advisor Robert W. Sobol, PhD Dissertation DNA Glycosylases as Modulators of Chemotherapeutic Response Man Yan Wong (MED '12) Advisor Edwin S. Levitan, PhD Dissertation Delivery and Exocytosis of Neuropetide Vesicles at the Nerve Terminal Serah E Choi (MED '11) Advisor Christopher Bakkenist, PhD Dissertation Preclinical Studies on ATM Kinase Inhibitors As Anti-Cancer Agents Amy M Furda Romesberg (MED '11) Advisor Ben Van Houten, PhD Dissertation The role of mtDNA damage in mitochondrial dysfunction Eva M Goellner (MED '11) Advisor Robert W. Sobol, PhD Dissertation Demonstrating functional crosstalk between DNA base excision repair and cellular bioenergetics: A strategy for the treatment of chemotherapy resistant glioblastoma Melanie J Grubisha (MED '11) Advisor Donald B. DeFranco, PhD Dissertation TGFBeta-Dependent ROS Regulates a Local Endocrine Communication Network Between Stromal and Epithelial Cells in the Prostate Courtney R LaValle (MED '11) Advisor Qiming Jane Wang, PhD Dissertation Targeting Protein Kinase D by Novel Small Molecule Inhibitors and RNA Interference in Prostate Cancer Nicholas W Bateman (MED '10) Advisor Thomas P. Conrads, PhD Dissertation A Proteomic Analysis of Neoplastic Progression in Breast Cancer Austin Dulak (MED '10) Advisor Jill M. Siegfried, PhD Dissertation Analyzing the Impact of EGFR-induced c-Met Phosphorylation in Non-Small Cell Lung Cancer Sangeetha Iyer (MED '10) Advisor Gregg E. Homanics, PhD Dissertation Role of the Alpha 4-containing GABA A Receptors in anesthetic and Ethanol Antagonist Effects: Insights from a Global Knockout Mouse Model Carolyn A Kitchens (MED '10) Advisor John S. Lazo, PhD Dissertation Exploitation of Small Interfering RNA Methodology to Identify Novel Anticancer Treatments Yan Wang (MED '10) Advisor John S. Lazo, PhD Dissertation Uncovering the Biological Functions of Phosphatase of Regenerating Liver-2 David Wheeler (MED '10) Advisor Peter A. Friedman, PhD Guillermo G. Romero, PhD Dissertation The PDZ adaptor protein, NHERF1, organizes and regulates protein complexes at the cell membrane Neil Bhola (MED '09) Advisor Jennifer Grandis, MD Dissertation Investigation of the mechanisms and therapeutic implications of crosstalk between G-protein-coupled receptors and the Epidermal Growth Factor Receptor in HNSCC Alison Groeger (MED '09) Advisor Bruce A. Freeman, PhD Dissertation Discovery and Characterization of Inflammation-induced Electrophilic Fatty Acid Derivatives Michael Hezel (MED '09) Advisor Ferruccio Galbiati, PhD Dissertation LGMD-1C: Role of Caveolin-3 in Neuromuscular Junction Structure and Function Teodora Pene-Dumitrescu (MED '09) Advisor Thomas E. Smithgall, PhD Dissertation Investigating the SRC kinase HCK functions in Chronic Myelogenous Leukemia using chemical genetics methods Pierre Queiroz de Oliveira (MED '09) Advisor John S. Lazo, PhD Dissertation Elucidating the role of Cdc25A in hypoxia-mediated cell cycle arrest Miranda Sarachine (MED '09) Advisor Billy Day, PhD Dissertation Roles of the Estrogen Receptors and the Nuclear Matrix in Breast Cancer Development and Tamoxifen Resistance Joshua Snyder (MED '09) Advisor Barry R. Stripp, PhD Dissertation Epithelial Reparative Capacity Regulates Extracellular Matrix Dynamics and Innate Immunity Alexander Bank (MED '08) Advisor Lin Zhang, PhD Dissertation The Role of SMAC in NSAID-induced Apoptosis Janine N Bartholomew (MED '08) Advisor Ferruccio Galbiati, PhD Dissertation Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer John Caltagarone (MED '08) Advisor Donald B. DeFranco, PhD Dissertation Differential Localization of Hic-5 and Paxillin in the Brain of Alzheimer's Disease Subjects Dev Chandra (MED '08) Advisor Gregg E. Homanics, PhD Dissertation Extrasynaptic GABA Type A Receptors in the Mechanism of Action of Ethanol Peter R McDonald (MED '08) Advisor John S. Lazo, PhD Dissertation Identification of Novel Potential Cancer Therapies by Synthetic Lethal Screening Robert Tomko (MED '08) Advisor John S. Lazo, PhD Dissertation Cellular and Biochemical Regulation of Cdc25A Phosphatase by Nitrosative Stress Pallavi Bansal (MED '07) Advisor John S. Lazo, PhD Dissertation Induction of CD25B Following DNA Damage: Implications for Cell Cycle Resumption and Tumorigenesis Gregory N Gan (MED '07) Advisor Richard D. Wood, Ph.D. Dissertation Human REV3L Expression and Protein Interaction Studies Jenny J Linnoila (MED '07) Advisor Zuo-Zhong Wang, PhD Dissertation T1di Mediates Agrin and Muscle Specific Kinase Signaling at the Neuromuscular Junction Hirdesh Uppal (MED '07) Advisor Wen Xie, MD, PhD Dissertation Regulatory Networks of PXR, Car and LXR in Cholesterol and Bile Acid Metabolism David F Werner (MED '07) Advisor Gregg E. Homanics, PhD Dissertation Elucidating the Role of a i-Contacting Gaba (A) Receptors in Ethanol Action John H Dubinion (MED '06) Advisor Edwin K. Jackson, PhD Dissertation Modulation of Angiotensin II-Induced Renal Vascular Presponses by PP-Fold Peptides Maria S Santos (MED '06) Advisor Ian J. Reynolds, PhD Dissertation Mitochondrial DNA in neurons and its modulation by neurotoxins Elena Sirbu (MED '06) Advisor Mark Nichols, PhD Dissertation Screening Assay for Selective Estrogen Receptor Modulators (2006) Prajakta Sonalker (MED '06) Advisor Edwin K. Jackson, PhD Dissertation The Renal Bumetaride-Sensitive Na-K-2Cl Cotransporter BSC-1/NKCO2 in Essential Hypertension and Its Regulation by Norepinephrine Diane T.W. Chang (MED '05) Advisor Ian J. Reynolds, PhD Dissertation Mitochondrial Trafficking in Healthy and Injured Neurons (2005) Lori Emert-Sedlak (MED '05) Advisor Daniel Johnson, PhD Dissertation Meditation of Chemotherapy-Induced Apoptosis by the Lysosomal Protease Cathespin D Catherine Kraft (MED '05) Advisor Guillermo G. Romero, PhD Dissertation Lipid Binding and the Scaffolding function of the Kinase Suppressor of Ras Latha Malaiyandi (MED '05) Advisor Ian J. Reynolds, PhD Dissertation Interactions between Zinc and Mitochondria in Neuronal Injury Julie Myers-Irvin (MED '05) Advisor Robert Getzenberg, PhD Dissertation Characterization of Nuclear Matrix Alterations Involved in Bladder Cancer Progression Qing Zhang (MED '05) Advisor Jennifer Grandis, MD Alex Ducruet (MED '04) Advisor John S. Lazo, PhD Dissertation Regulation of CDC25A in Human Tumor Cells by Cyclin-Dependent Kinase 2 Susana Montoya (MED '04) Advisor John S. Lazo, PhD Dissertation Evaluation of the Physiological Functions of Bleomycin Hydrolase in the Murine CNS Brad Andresen (MED '02) Advisor Guillermo G. Romero, PhD Dissertation Angiotensin II Signaling to Phospholipase D in a Model of Genetic Hypertension Ron Bernardi (MED '02) Advisor Candace S. Johnson, PhD Dissertation Vitamin D in Cancer Therapy: Mechanistic Studies and Novel Combinations Kirk Dineley (MED '02) Advisor Ian J. Reynolds, PhD Dissertation An Investigation of the Neurotoxic Properties of Zinc Lefteris Zacharia (MED '02) Advisor Edwin K. Jackson, PhD Dissertation Protective Role of the 2-Hydroxyesteradiol Methylation Pathway in the Cardiovascular and Renal Systems: Interaction with Catecholamines Yuen-Keng Ng (MED '01) Advisor Edwin S. Levitan, PhD Dissertation Enhancement of Neuropeptide Release by Increasing the Mobility of Secretory Granuler Yadi Tan (MED '01) Advisor Leaf Huang, PhD Dissertation Overcoming the Inflammatory Toxicity in Cationic Lipid Vector Mediated System Gene Delivery Ting-Ting Zhang (MED '01) Advisor Edwin S. Levitan, PhD Dissertation Regulation of KU4.3 and KV1.5KV Potassium Channel Expression in Cardiac Mycytes and GH3 Pituitary Cells Mark Rizzo (MED '00) Advisor Guillermo G. Romero, PhD Dissertation The Role of Phospholipase D in the Regulation of the Mitogen-Activated Protein Kinase Cascade Joelle Scanlon (MED '00) Advisor Ian J. Reynolds, PhD Dissertation The Role of Mitochondria in Glutamate-Induced Neuronal Injury Mark Whitmore (MED '00) Advisor Leaf Huang, PhD Dissertation Antitumor Activity of the LPD Lipopolyplex Prepared with Immunostimulatory CpG DNA