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Freeman Lab

The basic investigation and clinical research activities of the Freeman Laboratory focus on the eukaryotic cell production, reactions and signal transduction properties of oxidizing and free radical inflammatory mediators (e.g., superoxide, hydrogen peroxide, nitric oxide (NO), peroxynitrite, nitrogen dioxide, oxidized/nitrated lipids).  In particular, we are interested in the actions of these species as both redox signaling mediators, as pathogenic agents in inflammatory diseases and in the case of nitro-fatty acids as drug candidates.  Our observations regarding O2 and NO-derived reactive species have lent new insight into mechanisms of redox-dependent cell signaling, post-translational protein modification and have revealed new therapeutic strategies for treating acute inflammation, metabolic syndrome, respiratory disorders and cardiovascular diseases.

Marco Fazzari, PhD

Dr Fazzari’s research is focused on studying the generation, pharmacokinetics, and signaling actions of electrophilic lipid signaling mediators, to develop a pharmacological strategy for the treatment of cardiovascular diseases (CVD) and Parkinson’s disease (PD). The following research projects have generated very exciting results as well as grant support:
Project 1 – To evaluate nitro-nitrate fatty acid (NO2-ONO2-FA) derivatives as novel cGMP-dependent and cGMP-independent signaling mediators.