Dr Fazzari’s research is focused on studying the generation, pharmacokinetics, and signaling actions of electrophilic lipid signaling mediators, to develop a pharmacological strategy for the treatment of cardiovascular diseases (CVD) and Parkinson’s disease (PD). The following research projects have generated very exciting results as well as grant support: Project 1 – To evaluate nitro-nitrate fatty acid (NO2-ONO2-FA) derivatives as novel cGMP-dependent and cGMP-independent signaling mediators.