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Lei Wang, PhD

Research Instructor
W1311 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15260
lew72@pitt.edu
Phone: 412-419-8438

Education

BS (Biological Science), University of Science and Technology of China (China), 2009

PhD (Structure Biology and Biochemistry), University of Science and Technology of China (China), 2015
 
Headshot of Lei Wang, PhD
Research interests include the structural mechanisms of several G protein-coupled receptors (GPCRs) that play roles in human metabolic homeostasis, in particular (1) solving structures of vasopressin V2 receptor (V2R), prostaglandin D2 receptor (CRTH2), dopamine receptor and formylpeptide receptor bound with pharmacologically relevant ligands and signaling molecules, (2) performing related molecular studies to understand the pharmacological mechanism of GPCR signaling. Another research interest is using yeast display to develop functional antibodies and engineer proteins to regulate activities of immune receptors that regulating the functions of macrophages and T cells including GPCRs.
 

Journal Articles

H Liu, RNV Krishna Deepak, A Shiriaeva, C Gati, A Batyuk, H Hu, U Weierstall, W Liu, L Wang, V Cherezov, H Fan and C Zhang. Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2. Proc. Natl. Acad. Sci. USA. 118(32) e2102813118, 2021.
 
L Wang, J Xu, S Cao, D Sun, H Liu, Q Lu, Z Liu, Y Du and C Zhang. Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex. Cell Research 31:932-934, 2021.
 
Y Zhuang, P Xu, C Mao, L Wang, B Krumm, XE Zhou, S Huang, H Liu, X Cheng, X-P Huang, D Sheng, T Xu, Y-F Liu, Y Wang, J Guo, Y Jiang, H Jiang, K Melcher, BL Roth, Y Zhang, C Zhang and HE Xu. Structure of the human D1 and D2 dopamine signaling complexes. Cell 184(4):931-942.e18, 2021.
 
Y Zhuang, H Liu, XE Zhou, RK Verma, P de Waal, W Jang, T-H Xu, L Wang, X Meng, G Zhao, Y Kang, K Melcher, H Fan, N Lambert, HE Xu and C Zhang. Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling. Nature Communications 14:11(1):885, 2020.
 
Q Xiao, L Wang, S Supekar, T Shen, H Liu, F Ye, JZ Huang, H Fan, Z Wei and C Zhang. Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride. Nature Communications 11(1): 5430, 2020.
 
L Wang, D Yao, RNV Krishna Deepak, H Liu, Q Xiao, H Fan, W Gong, Z Wei and C Zhang. Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Molecular Cell 72(1):48-59.e4, 2018.
 
H Liu, HR Kim, RNV Krishna Deepak, L Wang, KY Chung, H Fan, Z Wei and C Zhang. Orthosteric and allosteric action of the C5a receptor antagonists. Nature Structural & Molecular Biology 25(6):472-481, 2018.