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"Directionality of Mitochondrial Electron Transpor...
Pharmacology & Chemical Biology Seminar Series
3/7/2024 - 12:00 PM-1:00 PM
"Directionality of Mitochondrial Electron Transport in Cardiac Ischemia & Reperfusion"
Paul S. Brookes, PhD
Professor
Department of Anesthesiology and Perioperative Medicine
University of Rochester Medical Center
First, I will discuss controversies regarding whether mitochondrial complex II (succinate dehydrogenase) can really operate in two directions in a physiologically relevant setting, compared to isolated mitochondria. I will then address the extracellular/intracellular fate of succinate in cardiac reperfusion. Finally, I will discuss recent work on the reversal (or not) of mitochondrial complex I as a source of ROS during reperfusion. Implications for therapeutic approaches to cardiac ischemia/reperfusion will also be discussed.
Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
200 Lothrop St
Pittsburgh, PA 15213
Contact
Melanie Hoffner