Skip to Main Content
Pitt Home
Find People
School of Medicine
Toggle navigation
Skip Navigation Links
Home
About
Leadership
Mission
Department Statistics
Building Information
Thomas E. Starzl BST
Biomedical Science Tower 3
Directory
Primary Faculty
Secondary Faculty
Graduate Students
Fellows
Administrative Staff
Research Staff
Adjunct Faculty
Department Alumni
Research
Research Areas
Labs
Equipment
Funding Opportunities
Faculty Development Program
Responsible Conduct of Research
Shops
Cell Biology/Pharmacology Machine Shop
Education
Molecular Pharmacology Graduate Program
Current Students
Current Student Roster
Student Publications
Diversity, Accessibility, and Counseling
Student Awards
MPGP News
Prospective Students
Welcome from the Director
Research Opportunities
PhD Track
MD/PhD Track
Financial Aid
Graduate Faculty
Graduate Courses
Grad Student Lab Rotations
Grad Student Events
Grad Student Event Calendar
Graduate Student Event Schedule
Alumni/Career Development
Alumni
Alumni Contacts
Molecular Pharmacology Facebook Group
Molecular Pharmacology Student-Alumni Network (LinkedIn)
SOM Graduate Studies - Career and Professional Development
Executive Committee
Student Testimonials
IBGP
Grad Student Funding Opportunities
NIH T32 Training Grant
Outcomes
Predoctoral Fellowship
Admissions
Student Handbook & General Timeline
Links
Useful Links
School of Medicine
PubMed
Remote Resources
Biomedical Masters Program
Undergraduate Research
Summer Fellowships
Lab Rotations
Graduate Fellowships
News
Events
Calendar
Seminar Series
Links
Contact
Opportunities
Department
PORtal
Computer Resources Access Request
IT-Equipment-Facilities Support Request
Poster Requests
Reservation Calendars
Badge Access Request
Keri J. Fogle, PhD
Research Instructor
Education
B.S. (Biochemistry), Duquesne University, Pittsburgh, PA, 2000 M.A. (Neurobiology), Columbia University, New York, NY, 2003 Ph.D. (Neurobiology), Columbia University, New York, NY, 2007
Research Details
Publications
Labs
Palladino Lab
Research Areas
Metabolic Syndrome Pharmacology
Neuropharmacology
Redox Pharmacology
The ATP61 Drosophila model of mitochondrial encephalomyopathies shares common features with human diseases, including Maternally Inherited Leigh Syndrome (MILS) and Neuropathy, Ataxia, and Retinitis Pigmentosa (NARP). Some of the hallmarks of these diseases include neurodegeneration and seizure-like activity that is often unresponsive to commonly-used anti-epileptic drugs.
Dr. Fogle is using whole-cell patch clamp electrophysiology of the intact fly brain to explore the molecular mechanisms which underlie the neurobiological symptoms in the ATP61 model, specifically the membrane channel complexes which may couple metabolic disruption to neuronal dysfunction and hyperexcitability, and thus represent targets for novel therapeutic interventions.
Journal Articles
Fogle KJ
, KP Parson, NA Damn and TC Holmes. Cryptochrome is a blue light sensor that modulates neuronal activity. Science 331:1409-1413, 2011.
Sheeba V,
KJ Vogle
and TC Holmes. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS ONE 5:e11628, 2010.
Rozario AO, HK Turbendian,
KJ Fogle
, NB Olivier and GR Tibbs. Voltage-dependent opening of HCN channels: Facilitation by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring. Biochim Biophys Acta 88:1939-1949, 2009.
Ayaz D, M Leyssen, M Koch, J Yan, M Srahna, V Sheeba,
KJ Fogle
, TC Holmes and BA Hassan. Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci 28:6010-6021, 2008.
Sheeba V,
KJ Fogle
, M Kaneko, S Rashid, YT Chou, VK Sharma and TC Holmes. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Current Biology 18:1537-1545, 2008.
Fogle KJ
, AK Lyaschenko, HK Turbendian and GR Gibbs. HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2. J Neurosci 27:2802-2814, 2007.