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Pharmacology & Chemical Biology Seminar Series
10/27/2022 - 12:00 PM-1:00 PM
“cAMP signaling at the nanometer scale”

Prof. Dr. Andreas Bock 
Medical Faculty
Leipzig University
Rudolf-Boehm-Institute of Pharmacology and Toxicology

G protein-coupled receptors (GPCRs) form the largest family of cell membrane receptors and modulate almost any (patho)physiological process in humans. GPCR signaling involves activation of distinct G-protein families, modulation of multiple intracellular second messengers, such as cAMP, and activation of kinases. Therefore, GPCRs orchestrate overwhelmingly complex intracellular signaling networks that are capable of precisely relaying signals in space and time to exert a myriad of specific cell functions. 
To ensure signaling specificity, GPCRs and their downstream signals are compartmentalized in very small regions in the cell that are called nanodomains. In my talk, I will introduce the concept of signaling compartmentation and highlight our recent work on cAMP nanodomains. Disruption of GPCR signaling networks can lead to noncommunicable diseases such as heart failure and cancer, and I will briefly discuss potential roles of nanodomain signaling in such diseases.  


Melanie Hoffner

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