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Recent Student Publications
Olayemi Akinyele
Brignoli, T., Douglas, E., Duggan, S.,
Fagunloye, O. G
., Adhikari, R., Aman, M. J., & Massey, R. C. (2022). Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus. Microbiology spectrum, e0101122. Advance online publication. https://doi.org/10.1128/spectrum.01011-22
Wenxi An
Reyes C, An W, Mo L, St Croix C, Shiva S. Nitrite inhibits mitofusin-1 degradation to attenuate vascular smooth muscle proliferation. In Preparation (to be submitted by July 31, 2021 to Atherosclerosis, Thrombosis and Vascular Biology)
Caitlyn Chapman
Chapman, C. A
.*, Nuwer, J. L.*, & Jacob, T. C. (2022). The yin and yang of gabaergic and glutamatergic synaptic plasticity: opposites in balance by crosstalking mechanisms. Frontiers in Synaptic Neuroscience, 14, 911020. https://doi.org/10.3389/fnsyn.2022.911020
Kaylee Ermine
Kuang C, Tong J,
Ermine K
, Cai M, Dai F, Hao S, Giles F, Huang Y, Yu J, Zhang L. Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death. Front Oncol. 2022 Oct 12;12:1018775. doi: 10.3389/fonc.2022.1018775. eCollection 2022. PMID: 36313707
Tong J, Tan X, Song X, Gao M, Risnik D, Hao S,
Ermine K
, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022 Apr 1;82(7):1340-1352. doi: 10.1158/0008-5472.CAN-21-3062. PMID: 35149588; PMCID: PMC8983601.
Christian Goossen
Jones, S. P.,
Goossen, C.
, Lewis, S. D., Delaney, A. M., & Gleghorn, M. L. (2022). Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase-RNA complexes.
Journal of Structural Biology
: X, 6, 100066
Robert Hall
Hall R
, Yuan S, Wood K, Katona M, Straub AC. Cytochrome b5 reductases: Redox regulators of cell homeostasis. J Biol Chem. 2022 Dec;298(12):102654. doi: 10.1016/j.jbc.2022.102654. Epub 2022 Oct 29. PMID: 36441026; PMCID: PMC9706631.
Carew NT, Schmidt HM, Yuan S, Galley JC,
Hall R
, Altmann HM, Hahn SA, Miller MP, Wood KC, Gabris B, Stapleton MC, Hartwick S, Fazzari M, Wu YL, Trebak M, Kaufman BA, McTiernan CF, Schopfer FJ, Navas P, Thibodeau PH, McNamara DM, Salama G, Straub AC. Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death. J Clin Invest. 2022 Sep 15;132(18):e147120. doi: 10.1172/JCI147120. PMID: 36106636; PMCID: PMC9479700
Trey Harkness
Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H,
Harkness T
, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022 Oct;56:102443. doi: 10.1016/j.redox.2022.102443. Epub 2022 Aug 24. PMID: 36058112; PMCID: PMC9450138.
Victoria Heinrich
Heinrich VA, Manni ML, Morris A, Wendell SG. Microbial-derived, systemic mediators and lung pathophysiology in obesity-associated asthma. Review in preparation.
Santos-Lopez A, Fritz MJ, Lombardo JB, Burr AHP,
Heinrich VA
, Marshall CW, Cooper VS. Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply
. Evolution, Medicine, and Public Health
. 2022;10(1):266-276.
Manni ML,
Heinrich VA
, Uvalle CE, Manuel A, Ellgass MR, Mullett SJ, Normann MC, Koziel C, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SL. Systemic bile acids potentiate airway hyperresponsiveness and modulate Th17 cell function in obesity-associated asthma.
The Journal of Immunology
2022;208:109.10-109.10.
Angela Hinchie
Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science. 2022 Nov 11;378(6620):664-668. doi: 10.1126/science.abq0607. Epub 2022 Nov 10.
Matthew Keeney
Marco Fazzari, Roberto Di Maio, Matthew Keeney et al. Neuroprotective actions of a fatty acid nitroalkene in Parkinson’s disease., 30 December 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-2367066/v1]
Keeney MT
, Hoffman EK, Farmer K, Bodle CR, Fazzari M, Zharikov A, Castro SL, Hu X, Mortimer A, Kofler JK, Cifuentes-Pagano E, Pagano PJ, Burton EA, Hastings TG, Greenamyre JT, Di Maio R. NADPH oxidase 2 activity in Parkinson's disease. Neurobiol Dis. 2022 Aug;170:105754. doi: 10.1016/j.nbd.2022.105754. Epub 2022 May 13. PMID: 35577065; PMCID: PMC9284948.
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W,
Keeney MT
, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR, Carr SA, Lindquist S, De Jager PL, Bartel DP, Myers CL, Greenamyre JT, Feany MB, Sunyaev SR, Chung CY, Khurana V. The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell. 2022 Jun 09;185(12):2035-2056.e33. pii: S0092-8674(22)00592-X.
Rocha EM,
Keeney MT
, Di Maio R, De Miranda BR, Greenamyre JT. LRRK2 and idiopathic Parkinson's disease. Trends Neurosci. 2022 Mar;45(3):224-236. pii: S0166-2236(21)00250-2. Epub 2022 Jan 04.
Michelle Lynskey
Bhargava R,
Lynskey ML
, O'Sullivan RJ. New twists to the ALTernative endings at telomeres. DNA Repair (Amst). 2022 Jul;115:103342. doi: 10.1016/j.dnarep.2022.103342. Epub 2022 May 13. PMID: 35588569; PMCID: PMC9675980.
Bellina Mushala
Mushala, B
., Xie, B., Sipula, I., Stoner, MW., Thapa, D., Manning, JR., Bugga, P., Vandevender, AM., Jurczak, MJ., & Scott, I. (2022). G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction
. biorxiv
. 2022.10.29.514377. Preprint.
Thapa D, Xie B, Mushala BAS, Zhang M, Manning JR, Bugga P, Stoner MW, Jurczak MJ, Scott I. Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment. Curr Res Physiol. 2022 Jan 25;5:55-62. doi: 10.1016/j.crphys.2022.01.005. PMID: 35128468; PMCID: PMC8803554.
Sripriya Raja
Nagpal A,
Raja S
, Van Houten B; The role of UV-DDB in processing 8-oxoguanine during base excision repair. Biochem Soc Trans 31 October 2022; 50 (5): 1481–1488. doi:
https://doi.org/10.1042/BST20220748
Hayley Rein
Prakash R, Sandoval T, Morati F, Zagelbaum JA, Lim PX, White T, Taylor B, Wang R, Desclos ECB, Sullivan MR,
Rein HL
, Bernstein KA, Krawczyk PM, Gautier J, Modesti M, Vanoli F, Jasin M. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nat Commun. 2021 Jul 12;12(1):4255. doi: 10.1038/s41467-021-24205-6. PMID: 34253720; PMCID: PMC8275761.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ,
Rein HL
, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. Epub 2022 Sep 13. PMID: 36099300; PMCID: PMC9499524.
Sofya Savransky
Peña KA, White AD,
Savransky S
, Castillo IP, Jean-Alphonse FG, Gardella TJ, Sutkeviciute I, Vilardaga JP. Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36. J Biol Chem. 2022 Sep;298(9):102332. doi: 10.1016/j.jbc.2022.102332. Epub 2022 Aug 4. PMID: 35933010; PMCID: PMC9437850.
Langowski MD, Khan FA,
Savransky S
, Brown DR, Balasubramaniyam A, Harrison WB, Zou X, Beck Z, Matyas GR, Regules JA, Miller R, Soisson LA, Batchelor AH, Dutta S. Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum. NPJ Vaccines. 2022 Jan 27;7(1):13. doi: 10.1038/s41541-022-00430-y. Epub 2022 Jan 27.