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Krystle Frahm, PhD

Research Assistant Professor
Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213
Fax: 412-648-1945


BA (Psychology), Texas State University, San Marcos, TX  2005
MA (Health Psychology), Texas State University, San Marcos, TX  2007
PhD (Cell and Molecular Biology), Colorado State University, Fort Collins, CO, 2014
Headshot of Krystle Frahm, PhD
Dr. Frahm's research interests focus on how endogenous and exogenous factors disrupt neuroendocrine development and function resulting in long-lasting physiological and behavioral consequences. Current studies are examining the role of glucocorticoid signaling during fetal development and in adulthood using genome-wide analysis and behavioral phenotyping. These collectively will provide insights into how altered hypothalamic output and can contribute to altered energy homeostasis and stress responses in a sex-specific manner.

Journal Articles

Frahm KA, Waldman JK, Luthra S, Rudine AC, Monaghan-Nichols AP, Chandran U and, DeFranco DB. A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol 471:42-50,2018.
Frahm KA, Handa RJ and Tobet SA. Embryonic exposure to dexamethasone impacts non-neuronal cells in the adult paraventricular nucleus of the hypothalamus. J Endocr Soc 2(2):140-153, 2017.
Liu TT, Grubisha MJ, Frahm KA, Wendell SG, Liu J, Ricke WA, Auchus RJ and DeFranco DB. (2016). Opposing effects of COX-2 on ER-beta response to 5alpha-reductase inhibition in prostate epithelial cells. J Biol Chem 291(28):14747-14760, 2016.
Frahm KA, Peffer ME, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan-Nichols AP and  DeFranco DB. The dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol Endocrinol 30(1):144-154, 2016.
Frahm KA and Tobet SA. Development of the blood-brain barrier within the paraventricular nucleus of the hypothalamus: Influence of fetal glucocorticoid excess. Brain Struct Funct 220(4):2225-2234, 2015.
Frahm KA, Nash CP and Tobet SA. Endocan immunoreactivity in the mouse brain: Method for identifying nonfunctional blood vessels. J Immunol Methods 398-399:27-32, 2013. 
Frahm KA, Schow MJ and Tobet SA. The vasculature within the paraventricular nucleus of the hypothalamus in mice varies as a function of development, sub-nuclear location, and GABA signaling. Horm Metab Res 44(8):619-624, 2012.