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Primary Faculty
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Krystle Frahm, PhD
Krystle Frahm, PhD
Research Assistant Professor
Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213
kaf130@pitt.edu
Fax: 412-648-1945
Education
BA (Psychology), Texas State University, San Marcos, TX 2005
MA (Health Psychology), Texas State University, San Marcos, TX 2007
PhD (Cell and Molecular Biology), Colorado State University, Fort Collins, CO, 2014
Research Details
Publications
Labs
DeFranco Lab
Research Areas
Endocrine Pharmacology/Physiology
Hormone Signaling and Action
Neuropharmacology
Dr. Frahm's research interests focus on how endogenous and exogenous factors disrupt neuroendocrine development and function resulting in long-lasting physiological and behavioral consequences. Current studies are examining the role of glucocorticoid signaling during fetal development and in adulthood using genome-wide analysis and behavioral phenotyping. These collectively will provide insights into how altered hypothalamic output and can contribute to altered energy homeostasis and stress responses in a sex-specific manner.
Journal Articles
Frahm KA
, Waldman JK, Luthra S, Rudine AC, Monaghan-Nichols AP, Chandran U and, DeFranco DB. A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol 471:42-50,2018.
Frahm KA
, Handa RJ and Tobet SA. Embryonic exposure to dexamethasone impacts non-neuronal cells in the adult paraventricular nucleus of the hypothalamus. J Endocr Soc 2(2):140-153, 2017.
Liu TT, Grubisha MJ,
Frahm KA
, Wendell SG, Liu J, Ricke WA, Auchus RJ and DeFranco DB. (2016). Opposing effects of COX-2 on ER-beta response to 5alpha-reductase inhibition in prostate epithelial cells. J Biol Chem 291(28):14747-14760, 2016.
Frahm KA
, Peffer ME, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan-Nichols AP and DeFranco DB. The dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol Endocrinol 30(1):144-154, 2016.
Frahm KA
and Tobet SA. Development of the blood-brain barrier within the paraventricular nucleus of the hypothalamus: Influence of fetal glucocorticoid excess. Brain Struct Funct 220(4):2225-2234, 2015.
Frahm KA
, Nash CP and Tobet SA. Endocan immunoreactivity in the mouse brain: Method for identifying nonfunctional blood vessels. J Immunol Methods 398-399:27-32, 2013.
Frahm KA
, Schow MJ and Tobet SA. The vasculature within the paraventricular nucleus of the hypothalamus in mice varies as a function of development, sub-nuclear location, and GABA signaling. Horm Metab Res 44(8):619-624, 2012.