Cancer Pharmacology
Research efforts in cancer pharmacology include studies of the basic mechanisms of signal transduction associated with cell proliferation and apoptosis, the mechanisms of action of anti-neoplastic agents, the design and discovery of new drugs, basic mechanisms of DNA repair and DNA damage tolerance and the development of novel strategies for gene therapy

Emphasis is placed on the description and characterization of basic signaling mechanisms that constitute the targets of molecules used for cancer therapy and DNA damage and repair mechanisms that contribute to anti-neoplastic drug resistance. The regulation of tyrosine kinases, processing of proto-oncogenes, regulation of small GTPases and their effectors, cell-cycle-specific kinases and DNA repair gene products are being studied as potential targets or to enhance the efficacy of existing chemotherapeutic agents. The role of growth factors in the progression of solid and hematopoietic tumors is being studied; new receptors and signal transduction pathways are being identified in normal and malignant tissues.

Other areas of research include investigations on interleukin therapy, free radical generation, molecular mechanisms of antioxidant regulation and detoxification, aberrations in the mechanisms of programmed cell death (apoptosis) associated with tumoral growth and alterations in DNA repair and DNA damage response genes associated with tumor growth and chemotherapeutic resistance.

Faculty

altschul@pitt.edu
412.648.9751
cjb38@pitt.edu
412-623-7765
rjb42@pitt.edu
412-3.83-7722
burnstf@upmc.edu
412-864-7859
feg5@pitt.edu
412-648-2047
yuj5@pitt.edu
412-648-3390
kimsw2@upmc.edu
412-802-6393
arbelyy@upmc.edu
412-623-3228
can44@pitt.edu
412-641-7725
osullivanr@upmc.edu
412-623-4063
oesterreichs@upmc.edu
412-641-8555
jsiegfri@umn.edu
612-625-9997
svs2@pitt.edu
412-623-3262
tsmithga@pitt.edu
412-648-8106
steinman@pitt.edu
412-623-3237
qjw1@pitt.edu
412-383-7754
wangz2@upmc.edu
412-623-3903
zhanglx@upmc.edu
412-623-1009