Recent Student Publications

Yoast RE, Emrich SM, Zhang X, Xin P, Arige V, Pathak T, Benson JC, Johnson MT, Abdelnaby AE, Lakomski N, Hempel N, Han JM, Dupont G, Yule DI, Sneyd J, Trebak M. The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation. J Biol Chem. 2021 Oct;297(4):101174. doi: 10.1016/j.jbc.2021.101174. Epub 2021 Sep 6. PMID: 34499925; PMCID: PMC8496184.

Smith, Michael and Yadav, Swara and Akinyele, Olayemi and Pels, Nana Adjoa and Horton, Daniel and Alsultan, Nashwah and Borns, Andrea and Cousin, Carolyn and Dixon, Freddie and Mann, Victoria H. and Lee, Clarence and Brindley, Paul J. and El-Sayed, Najib M. and Bridger, Joanna M. and Knight, Matty. PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata. bioRxiv. 2021. doi:https://doi.org/10.1101/2021.01.12.426235

Zhu D, Dai W, Srinivasan P, McClellan H, Braden D, Allee-Munoz A, Hurtado PAG, Miller LH, Duffy PE. Characterization of AMA1-RON2L complex with native gel electrophoresis and capillary isoelectric focusing  Electrophoresis. 2021 Oct 22. doi: 10.1002/elps.202000365. Online ahead of print. PMID: 34679212

Garrudo FFF, Mikael PE, Xia K, Silva JC, Ouyang Y, Chapman CA, Hoffman PR, Yu Y, Han X, Rodrigues CAV, Cabral JMS, Morgado J, Ferreira FC, Linhardt RJ. The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells. Biochimie. 2021 Mar;182:61-72. doi: 10.1016/j.biochi.2021.01.001. Epub: 2021 Jan 7.

Wu L., Chatla S., Lin Q., Chowdhury, F.A., Geldenhuys W., Du W. (2021). Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia. Nat Commun. 2021 https://doi: 10.1038/s41467-021-27300-w. PMID: 34836965; PMCID: PMC8626516.

Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. ATM inhibition drives metabolic adaptation via induction of macropinocytosis. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. PMID: 36399181; PMCID: PMC9679964.

Zhang X, Connelly J, Chao Y, Wang QJ. Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.   Biomolecules. 2021 Mar 23;11(3):483. doi: 10.3390/biom11030483. PMID: 33807058  PMCID: PMC8005150
 

Zhang X, Connelly J, Levitan ES, Sun D, Wang JQ. Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.  Transl Stroke Res. 2021 Aug;12(4):513-529. doi: 10.1007/s12975-021-00901-9. Epub 2021 Mar 13. PMID: 33713030
 

Tong J, Tan X, Hao S, Ermine K, Lu X, Liu Z, Jha A, Yu J, Zhang L. Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene. 2023 Mar;42(12):869-880. doi: 10.1038/s41388-023-02598-6. Epub 2023 Jan 31. PMID: 36721000

Tong J, Tan X, Risnik D, Gao M, Song X, Ermine K, Shen L, Wang S, Yu J, Zhang L. BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. Oncogene. 2021 Dec;40(48):6566-6578. doi: 10.1038/s41388-021-02041-8. Epub 2021 Oct 6. PMID: 34615996; PMCID: PMC8642302.

Ermine K, Yu J, Zhang L. Role of Receptor Interacting Protein (RIP) kinases in cancer. Genes Dis. 2021 Nov 18;9(6):1579-1593. doi: 10.1016/j.gendis.2021.10.007. PMID: 36157481; PMCID: PMC9485196.

Li Y, Kracun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42). pii: e2015666118.

Acharya AP, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY.   Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.J Am Heart Assoc. 2021 Jun 15;10(12):e019091. doi: 10.1161/JAHA.120.019091. Epub 2021 May 29. PMID: 34056915
 

Woodcock CC, Hafeez N, Handen A, Tang Y, Harvey LD, Estephan LE, Speyer G, Kim S, Bertero T, Chan SY.     Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L726-L738. doi: 10.1152/ajplung.00407.2020. Epub 2021 Feb 10. PMID: 33565360   PMCID: PMC8174827
 

Manni ML, Heinrich VA, Buchan GJ, O’Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullet SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Scientific Reports. 2021; 11(1): 17788.

Sullivan, D.I.; Jiang, M.; Hinchie, A.M.; Roth, M.G.; Bahudhanapati, H.; Nouraie, M.; Liu, J.; McDyer, J.F.; Mallampalli, R.K.; Zhang, Y.; Kass, D.J.; Finkel, T.; Alder, J.K.Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line. Frontiers in Medicine. 9 February 2021;8. doi: 10.3389/fmed.2021.600626.

Di Maio R, Keeney MT, Cechova V, Mortimer A, Sekandari A, Rowart P, Greenamyre JT, Freeman BA, Fazzari M. Neuroprotective actions of a fatty acid nitroalkene in Parkinson's disease. NPJ Parkinsons Dis. 2023 Apr 7;9(1):55. doi: 10.1038/s41531-023-00502-3. PMID: 37029127; PMCID: PMC10082007.

Keeney, M. T., Hoffman, E. K., Greenamyre, J. T. and Di Maio, R. (2021). Measurement of LRRK2 Kinase Activity by Proximity Ligation Assay. Bio-protocol 11(17): e4140. DOI: 10.21769/BioProtoc.4140.

Bonilla B, Brown AI, Hengel SR, Rapchak KS, Mitchell D, Pressimone CA, Fagunloye AA, Luong TT, Russell RA, Vyas RK, Mertz TM, Zaher HS, Mosammaparast N, Malc EP, Mieczkowski PA, Roberts S, Bernstein KA. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Elife. 2021 Nov 1;10:e68080. doi: 10.7554/eLife.68080. Epub ahead of print. PMID: 34723799.

 

Grimley E, Cole AJ, Luong TT, McGonigal SC, Sinno S, Yang D, Bernstein KA, Buckanovich RJ. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021 Jan 20;11(8):3540-3551. doi: 10.7150/thno.51885. PMID: 33664846; PMCID: PMC7914353.
 

Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol Cell. 2023 May 18;83(10):1743-1760.e11. doi: 10.1016/j.molcel.2023.03.027. Epub 2023 Apr 27. PMID: 37116497; PMCID: PMC10205078.

Barroso-González J, García-Expósito L, Galaviz P, Lynskey ML, Allen JAM, Hoang S, Watkins SC, Pickett HA, O'Sullivan RJ. Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. Cell Rep. 2021 Dec 7;37(10):110088. doi: 10.1016/j.celrep.2021.110088. PMID: 34879271; PMCID: PMC8724847

Mushala BAS, Scott I. Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism. Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H238-H244. doi: 10.1152/ajpheart.00449.2020. Epub 2020 Nov 20. PMID: 33216612; PMCID: PMC7847067.

Jang S, Raja SJ, Roginskaya V, Schaich MA, Watkins SC, Van Houten B. UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties. Nucleic Acids Res. 2023 Mar 27:gkad206. doi: 10.1093/nar/gkad206. Online ahead of print. PMID: 36971122

Raja, S., & Van Houten, B. (2021). The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer. International journal of molecular sciences, 22(4), 1981. https://doi.org/10.3390/ijms22041981

Rein, H.L., Bernstein, K.A., and Baldock, R.A. (2021) RAD51 paralog function in replicative DNA damage and tolerance. Current Opinions in Genetics and Development, 71:86-91

Portales-Castillo I, Dean T, Cheloha RW, Creemer BA, Vilardaga JP, Savransky S, Khatri A, Jüppner H, Gardella TJ. Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome. Commun Biol. 2023 Jun 2;6(1):599. doi: 10.1038/s42003-023-04966-0. PMID: 37268817; PMCID: PMC10238420

Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. Precise druggability of the PTH type 1 receptor. Nat Chem Biol. 2022 Mar;18(3):272-280. doi: 10.1038/s41589-021-00929-w. Epub 2021 Dec 23.

Lewis, S.E., Rosencrance, C.B., DeVallance, E., Giromini, A., Williams, X.M., Oh, J., Schmidt, H.M., Straub, A.C., Chantler, P.D., Patel, R.P., Kelley, E.E., “Human and Rodent Red Blood Cells do not Demonstrate Xanthine Oxidase Activity or XO-Catalyzed Nitrite Reduction to NO,” Free Radical Biology and Medicine (2021).
 

Dosunmu-Ogunbi, A., Galley, J.C., Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation,” Hypertension (2021)
 

Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Coenzyme Q in cellular redox regulation and clinical heart failure”, Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2021.03.011 (2021).
 

Wu Y, Li Z, Wedn AM, Casey AN, Brown D, Rao SV, Omarjee S, Hooda J, Carroll JS, Gertz J, Atkinson JM, Lee AV, Oesterreich S. FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer. Mol Cancer Res. 2023 Jun 1;21(6):591-604. doi: 10.1158/1541-7786.MCR-22-0516. PMID: 36930833; PMCID: PMC10239325.

Longarini EJ, Dauben H, Locatelli C, Wondisford AR, Smith R, Muench C, Kolvenbach A, Lynskey ML, Pope A, Bonfiglio JJ, Jurado EP, Fajka-Boja R, Colby T, Schuller M, Ahel I, Timinszky G, O'Sullivan RJ, Huet S, Matic I. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol Cell. 2023 May 18;83(10):1743-1760.e11. doi: 10.1016/j.molcel.2023.03.027. Epub 2023 Apr 27. PMID: 37116497; PMCID: PMC10205078.

Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. PMID: 34019811; PMCID: PMC8221567.