Pharmacology of Cell and Organ Systems Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic synaptic transmission and the autonomic regulation of the urogenital and renal systems. These studies include: 1) neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs; 2) biochemical/molecular analysis of the role of PP-fold peptides released from autonomic synaptic junctions in the regulation of renovascular tone and arterial blood pressure in genetic hypertension; and 3) the interaction between the sympathetic nervous system and estradiol on renal function. Faculty Barchowsky, Aaron Professor, Environmental and Occupational HealthThe main focus of the research in the Barchowsky laboratory is the cellular and molecular mechanisms for pathogenic tissue remodeling and metabolic dysfunction caused by environmental metals exposures. The core theme of the research has been on meta... aab20@pitt.edu 412-624-8864 Bayir, Hülya Critical Care Medicine, Environmental and Occupational Health UPMC Chair in Critical Care Pediatric ResearchDr. Hülya Bayir’s research focuses on the primary themes of mitochondrial injury and oxidative signaling. She has organized a multidisciplinary team of investigators to study novel approaches to the treatment of mitochondrial dysfunction by targeting... bayihx@upmc.edu 412-692-5164 Beckel, Jonathan Associate ProfessorMolecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology jmbeckel@pitt.edu 412-383-5004 Binder, Robert Associate Professor of ImmunologyTumor immunology; Heat Shock Protein Immunobiology; Tumor immunosurveillance; biology of scavenger receptors in antigen crosspresentation; immune responses initiated by endogenous molecules. rjb42@pitt.edu 412-3.83-7722 Birder, Lori Professor, Medicine Study a number of ion channel/receptor targets within the bladder epithelium and the possible role of the urothelium in urinary bladder function. lbirder@pitt.edu 412-383-7368 Bisello, Alessandro Professor & Vice Chair for Experiential LearningStructure, signaling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function. alb138@pitt.edu 412-648-7347 DeFranco, Donald Professor & Vice Chair for Medical Education, Associate Dean for Medical Student ResearchGlucocorticoids and Neurodevelopment. Prostate cancer. dod1@pitt.edu 412-624-4259 Friedman, Peter ProfessorParathyroid hormone receptor trafficking, regulation, signaling. paf10@pitt.edu 412-383-7783 Jackson, Edwin Distinguished Professor The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites. edj@pitt.edu 412-648-1505 Kanai, Anthony Professor, Medicine Roles of the urothelium, interstitial cells and afferent nerves in urinary incontinence--studied using optical mapping. Nitric oxide in radiation cystitis and the mitochondrial targeting of radioprotectants. ajk5@pitt.edu 412-624-1430 Lee, Adrian Professor; Pittsburgh Foundation Chair in Precision Medicine leeav@upmc.edu 412-641-7557 Lotze, Michael Professor, Surgery and BioengineeringTumor immunology; dendritic cell biology; cytokine biology; regulation of apoptosis in immune effectors; role of the nuclear protein HMGB 1 in promoting inflammation, mRNA role in regulating the translation of proteins in macrophages and other inflam... lotzemt@upmc.edu 412-623-5977 Neumann, Carola Associate Professor & Vice Chair for Precision and Translational Pharmacology can44@pitt.edu 412-641-7725 Oesterreich, Steffi Professor, The Shear Family Foundation Chair in Breast Cancer ResearchMolecular mechanism and clinical relevance of endocrine response in breast cancer oesterreichs@upmc.edu 412-641-8555 Pagano, Patrick ProfessorDevelopment of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies pagano@pitt.edu 412-383-6505 Palladino, Michael Professor & Vice Chair for Faculty AffairsCombined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions mjp44@pitt.edu 412-383-5900 Romero, Guillermo Associate ProfessorRegulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases. ggr@pitt.edu 412-648-9408 Schopfer, Francisco Associate Professor & Vice Chair for Biotechnology Development fjs2@pitt.edu 412-648-0193 Shiva, Sruti Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine InstituteThe mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia. sss43@pitt.edu 412-383-5854 Straub, Adam Associate Professor & Vice Chair, ResearchRedox signaling mechanisms in the microcirculation. astraub@pitt.edu 412-648-7097 Trebak, Mohamed Professor trebakm@pitt.edu 412-648-1381 Van Houten, Ben ProfessorMitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins. vanhoutenb@upmc.edu 412-623-7762 Vilardaga, Jean-Pierre ProfessorUnderstanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking. jpv@pitt.edu 412-648-2055 Wang, Qiming Jane ProfessorTargeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer. qjw1@pitt.edu 412-383-7754 Xie, Wen Professor and Joseph Koslow Endowed Chair in Pharmaceutical Sciences Nuclear hormone receptor-mediated gene regulation in endrocrinology, gastroenterology, and cancer. Nuclear hormone receptors as therapeutic targets for metabolic syndrome. wex6@pitt.edu 412-648-9941