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Pharmacology & Chemical Biology Seminar Series
9/22/2022 - 12:00 PM-1:00 PM
"EROS: controlling the phagocyte respiratory burst and purinergic signaling"


Dr David Thomas MA MB BChir PhD MRCP (Neph) 
Reader in Immunity and Inflammation and Honorary, Consultant Nephrologist
Wellcome-Beit Clinical Research Career Dev Fellow, Imperial College London

I will outline our characterisation of EROS (CYBC1 gene), a hitherto undescribed protein that acts as a super-selective chaperone for the gp91phox subunit of the phagocyte NADPH oxidase as well as the ATP receptor P2X7. EROS-deficiency in both mouse and human causes a severe immunodeficiency. The talk will focus on its discovery, role in immune physiology and molecular mechanism of action.


Thomas E. Starzl Biomedical Science Tower
203 Lothrop St
Pittsburgh, PA 15213
Melanie Hoffner

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