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Hu Lab

Dr. Hu’s research focuses on understanding how posttranslational modification (PTM) of cancer-related factors—by phosphate, ubiquitin, and ubiquitin-related modifiers such as SUMO (small ubiquitin-related modifier-1)—regulates cellular process in cancer biology and treatment. Using various cellular and preclinical animal models, currently Dr. Hu is investigating the mechanistic and functional roles of phosphorylation of glycogen synthase kinase 3 (Gsk3, a key component of the Wnt/ß-catenin pathway) by tyrosine kinases in the biology of KRAS-driven pancreatic ductal adenocarcinoma (PDAC) and Wnt-driven intestinal tumorigenesis.
 

Jing Hu, PhD

Journal Articles

Gao C, G Chen, S-K Kuan, DH Zhang, DD Schlaepfer and J Hu.  FAK/PYK2 promotes the Wnt/B-catenin pathway and intestinal tumorigenesis by phosphorlyating G SK3ß.  eLife 10.7554/eLife.10072, 2015.
Gao C, G Chen, G. Romero, S Moschos, X Xu and J Hu.  Induction of Gsk3ß ubiquitination is required for the activation of the Wnt/ß-catenin pathway.  J Biol Chem 289:7099-7108, 2014.
Xu X, J Vatsyayan, C Gao, CJ Bakkenist and J Hu.  HDAC2 promotes eIF4E sumoylation and activates mRNA translation specifically.  J Biol Chem285:18139-18143, 2010.
Xu X, J Vatsyayan, C Rao, CJ Bakkenist and J Hu. Sumoylation of eIF4E activates mRNA translation.  EMBO Reports 11:299-304, 2010.
Vatsyayan J, GL Qing, G Xiao and J Hu.  SUMO-1 modification of NF-?B2/p100 is essential for stimuli-induced p100 phosphorylation and processing.  EMBO Reports 9:885-890, 2008.
Hu J, J Straub, D Xiao, SV Singh, HS Yang, N Sonenberg and J Vatsyayan.  Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.  Cancer Res 67(8):3569-3573, 2007.