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University of Pittsburgh

Heidi Schmidt

Predoctoral Fellow

Education

BSE, Biomedical Engineering, Case Western Reserve University, 2017
Dissertation
(2022)

Research Summary

I am interested in studying the role of xanthine oxidase under conditions of excess circulating free heme in hemolytic diseases such as sickle cell disease.
 
Headshot of Heidi Schmidt

Labs

I am interested in studying the role of xanthine oxidase under conditions of excess circulating free heme in hemolytic diseases such as sickle cell disease.
 

Journal Articles

Lewis, S.E., Rosencrance, C.B., DeVallance, E., Giromini, A., Williams, X.M., Oh, J., Schmidt, H.M., Straub, A.C., Chantler, P.D., Patel, R.P., Kelley, E.E., “Human and Rodent Red Blood Cells do not Demonstrate Xanthine Oxidase Activity or XO-Catalyzed Nitrite Reduction to NO,” Free Radical Biology and Medicine (2021).
 
Dosunmu-Ogunbi, A., Galley, J.C., Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation,” Hypertension (2021)
 
Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Coenzyme Q in cellular redox regulation and clinical heart failure”, Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2021.03.011 (2021).
 
Schmidt HM, Wood KC, Lewis SE, Hahn SA, Williams XM, McMahon B, Baust JJ, Yuan S, Bachman TN, Wang Y, Oh JY, Ghosh S, Ofori-Acquah SF, Lebensburger JD, Patel RP, Du J, Vitturi DA, Kelley EE, Straub AC. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease.   Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):769-782. doi: 10.1161/ATVBAHA.120.315081. Epub 2020 Dec 3. PMID: 33267657   PMCID: PMC8185582
Kikuchi A, Singh S, Poddar M, Nakao T, Schmidt HM, Gayden JD, Sato T, Arteel GE, Monga SP.  Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.   Am J Pathol. 2020 Oct;190(10):2080-2094. doi: 10.1016/j.ajpath.2020.06.006. Epub 2020 Jun 29. PMID: 32615075  PMCID: PMC7527859
 
Kikuchi, A., Singh, S., Poddar, M., Nakao, T., Schmidt, H.M., Gayden, J.D., Sato, T., Arteel, G.E., Monga, S.P., “Hepatic stellate cell-specific platelet-derived growth factor receptor α loss reduces fibrosis and promotes repair following hepatocellular injury,” The American Journal of Pathology. doi: 10.1016/j.ajpath.2020.06.006. (2020)
 
Wood KC, Durgin BG, Schmidt HM, Hahn SA, Baust JJ, Bachman T, Vitturi DA, Ghosh S, Ofori-Acquah SF, Mora AL, Gladwin MT, Straub AC.  Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.  Blood Adv. 2019 Dec 10;3(23):4104-4116. doi: 10.1182/bloodadvances.2019000621. PMID: 31821458  PMCID: PMC6963246
Wood, K.C., Durgin, B.G., Schmidt, H.M., Hahn, S.A., Baust, J.J., Bachman, T., Vitturi, D.A., Ghosh, S., Ofori-Acquah, S.F., Mora, A.L., Gladwin, M.T., and Straub, A.C., “Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice,” Blood Advances. doi: 10.1182/bloodadvances.2019000621 (2019)
 
Durgin BG, Hahn SA, Schmidt HM, Miller MP, Hafeez N, Mathar I, Freitag D, Sandner P, Straub AC.   Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation. JCI Insight. 2019 Oct 3;4(19):e129183. doi: 10.1172/jci.insight.129183. PMID: 31487266  PMCID: PMC6795404
 
Durgin, B.G., Hahn, S.A., Schmidt, H.M., Miller, M.P., Hafeez, N., Mathar, I., Freitag, D., Sandner, P., and Straub, A.C., “Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation,” JCI Insight. doi: 10.1172/jci.insight.129183. (2019)
 
Schmidt, H.M., Kelley, E.E., Straub, A.S., “The impact of xanthine oxidase (XO) on hemolytic diseases,” Redox Biology. doi: 10.1016/j.redox.2018.101072 (2018)
 
Schmidt HM, Kelley EE, Straub AC.   The impact of xanthine oxidase (XO) on hemolytic diseases.  Redox Biol. 2019 Feb;21:101072. doi: 10.1016/j.redox.2018.101072. Epub 2018 Dec 10. PMID: 30580157  PMCID: PMC6305892
 

Awards and Honors

NIH F31 Investigating the Role of Xanthine Oxidase in Hemolytic Disease (Funded August 2019-August 2024)