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Pharmacology & Chemical Biology Seminar Series
3/16/2023 - 12:00 PM-1:00 PM
“The physiology of store operated calcium signaling in the brain”

Murali Prakriya, PhD 
Magerstadt Professor
Department of Pharmacology
Department of Medicine
Feinberg School of Medicine
Northwestern University

I will be talking about the molecular mechanisms and physiological roles of store-operated calcium channels in neurons and astroglia.  Our work indicates that the store-operated Orai1 channel plays a key role in regulating cognitive functions by regulating synaptic plasticity in neurons. Orai1 is additionally involved in mediating brain inflammation through microglial and astrocyte functions, which impacts syndromes such as neuropathic pain and inflammation-evoked depression. 


Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop St
Pittsburgh, PA 15213
Melanie Hoffner

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