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Home
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Research Areas
Research Areas
Primary faculty research interests in the department span several concentrations:
Benign Urologic Disorders
Cancer Genomics
Cancer Pharmacology
Cardiac Mechanisms of Pathogenesis
Cardiac Pharmacology
Cardiovascular and Renal Pharmacology
Clinical Pharmacology
DNA Repair
Drug Discovery
Endocrine Pharmacology/Physiology
Hormone Pharmacology
Hormone Signaling and Action
Metabolic Syndrome Pharmacology
Neuropharmacology
Pharmacology of Cell and Organ Systems
Protein Kinases & Phosphatases
Pulmonary Pharmacology
Purine Pharmacology
Receptor Pharmacology
Redox Pharmacology
Signal Transduction
Structural Pharmacology
Systems Biology of Cancer
Systems Pharmacology
Benign Urologic Disorders
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
de Groat, William
Distinguished Professor
Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms.
wcd2@pitt.edu
412-648-9357
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Pascal, Laura
Research Assistant Professor
lep44@pitt.edu
412-383-9564
Cancer Genomics
Faculty
Lee, Adrian
Professor; Pittsburgh Foundation Chair in Precision Medicine
leeav@upmc.edu
412-641-7557
Nechemia-Arbely, Yael
Assistant Professor
Research in the lab is focused on understanding the structure, composition and maintenance of the epigenetically defined human centromeres.
arbelyy@upmc.edu
412-623-3228
Cancer Pharmacology
Research efforts in cancer pharmacology include studies of the basic mechanisms of signal transduction associated with cell proliferation and apoptosis, the mechanisms of action of anti-neoplastic agents, the design and discovery of new drugs, basic mechanisms of DNA repair and DNA damage tolerance and the development of novel strategies for gene therapy
Emphasis is placed on the description and characterization of basic signaling mechanisms that constitute the targets of molecules used for cancer therapy and DNA damage and repair mechanisms that contribute to anti-neoplastic drug resistance. The regulation of tyrosine kinases, processing of proto-oncogenes, regulation of small GTPases and their effectors, cell-cycle-specific kinases and DNA repair gene products are being studied as potential targets or to enhance the efficacy of existing chemotherapeutic agents. The role of growth factors in the progression of solid and hematopoietic tumors is being studied; new receptors and signal transduction pathways are being identified in normal and malignant tissues.
Other areas of research include investigations on interleukin therapy, free radical generation, molecular mechanisms of antioxidant regulation and detoxification, aberrations in the mechanisms of programmed cell death (apoptosis) associated with tumoral growth and alterations in DNA repair and DNA damage response genes associated with tumor growth and chemotherapeutic resistance.
Faculty
Aird, Katherine
Associate Professor
kaa140@pitt.edu
412-623-7709
Altschuler, Daniel
Associate Professor
G-protein signaling mechanisms in mitogenesis and oncogenesis
altschul@pitt.edu
412.648.9751
Buj-Gomez, Raquel
Research Assistant Professor
rbg19@pitt.edu
412-623-3241
Galbiati, Ferruccio
Professor & Vice Chair for Research
Signal transduction mechanisms in muscular dystrophy and ageing/cancer.
feg5@pitt.edu
412-648-2047
Gelhaus, Stacy
Associate Professor; Scientific Director, Health Sciences Mass Spectrometry Core
gstacy@pitt.edu
412-648-1351
Hahm, Eun-Ryeong
Research Instructor
euh2@pitt.edu
412-623-3262
Huang, Yi
Assistant Professor
yih26@pitt.edu
412-641-3589
Jiang, Yu
Professor
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
yuj5@pitt.edu
412-648-3390
Nechemia-Arbely, Yael
Assistant Professor
Research in the lab is focused on understanding the structure, composition and maintenance of the epigenetically defined human centromeres.
arbelyy@upmc.edu
412-623-3228
Neumann, Carola
Associate Professor & Vice Chair for Precision and Translational Pharmacology
can44@pitt.edu
412-641-7725
O'Sullivan, Roderick
Associate Professor
Study of the consequences that defective chromatin assembly and altered epigenetic mechanisms may have in cancer and aging.
osullivanr@upmc.edu
412-623-4063
Oesterreich, Steffi
Professor, The Shear Family Foundation Chair in Breast Cancer Research
Molecular mechanism and clinical relevance of endocrine response in breast cancer
oesterreichs@upmc.edu
412-641-8555
Sharrow, Allison
Research Assistant Professor
AllisonSharrow@pitt.edu
Singh, Shivendra
Professor and UPMC Chair in Cancer Prevention Research
The Singh laboratory focuses on preclinical and clinical investigations of novel agents derived from dietary (eg, broccoli) and medicinal plants (eg, Withania somnifera) for chemoprevention of cancers.
svs2@pitt.edu
412-623-3262
Stabile, Laura
Research Associate Professor
stabilela@upmc.edu
412-623-2015
Trebak, Mohamed
Professor
trebakm@pitt.edu
412-648-1381
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Cardiac Mechanisms of Pathogenesis
Faculty
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Cardiac Pharmacology
Faculty
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Pagano, Patrick
Professor
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
pagano@pitt.edu
412-383-6505
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Cardiovascular and Renal Pharmacology
Faculty
Chang, Fei
Research Instructor
fec29@pitt.edu
530-219-1806
Fazzari, Marco
Research Assistant Professor
maf167@pitt.edu
412-626-2924
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Jackson, Edwin
Distinguished Professor
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites.
edj@pitt.edu
412-648-1505
Jiang, Yu
Professor
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
yuj5@pitt.edu
412-648-3390
Khoo, Nicholas
Research Assistant Professor
nkhoo@pitt.edu
412-648-9671
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Tofovic, Stevan
Associate Professor
tofovic@pitt.edu
412-648-3363
Trebak, Mohamed
Professor
trebakm@pitt.edu
412-648-1381
Clinical Pharmacology
Faculty
Tofovic, Stevan
Associate Professor
tofovic@pitt.edu
412-648-3363
DNA Repair
Faculty
Aird, Katherine
Associate Professor
kaa140@pitt.edu
412-623-7709
Buj-Gomez, Raquel
Research Assistant Professor
rbg19@pitt.edu
412-623-3241
O'Sullivan, Roderick
Associate Professor
Study of the consequences that defective chromatin assembly and altered epigenetic mechanisms may have in cancer and aging.
osullivanr@upmc.edu
412-623-4063
Van Houten, Ben
Professor
Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
vanhoutenb@upmc.edu
412-623-7762
Drug Discovery
Drug Discovery is an emerging pharmacological science that seeks to identify novel small molecule probes and to understand at a molecular level how compounds affect macromolecular process. Cell-based, in vitro mix-and-read, and whole organism assays suitable for rapid or high throughput analysis are being designed and implemented by members of the Molecular Pharmacology Program. Current molecular targets include Gprotein coupled receptors, vanilloid receptors, cathepsins, apoptosis-inducing proteins, ion channels, steroid receptors, orphan nuclear receptors, kinases, phosphatases, DNA repair enzymes, and DNA polymerases. Chemical libraries and automated screening instrumentation are emphasized, which permit rapid interrogation of optimized assays. Computational approaches and high content cell screening methodologies are employed to facilitate the identification of new chemical probes.
Faculty
Chang, Fei
Research Instructor
fec29@pitt.edu
530-219-1806
Cifuentes Pagano, Eugenia
Research Assistant Professor
mec110@pitt.edu
412-648-2610
Fazzari, Marco
Research Assistant Professor
maf167@pitt.edu
412-626-2924
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Huang, Yi
Assistant Professor
yih26@pitt.edu
412-641-3589
Jiang, Yu
Professor
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
yuj5@pitt.edu
412-648-3390
Pagano, Patrick
Professor
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
pagano@pitt.edu
412-383-6505
Palladino, Michael
Professor & Vice Chair for Faculty Affairs
Combined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions
mjp44@pitt.edu
412-383-5900
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Singh, Shivendra
Professor and UPMC Chair in Cancer Prevention Research
The Singh laboratory focuses on preclinical and clinical investigations of novel agents derived from dietary (eg, broccoli) and medicinal plants (eg, Withania somnifera) for chemoprevention of cancers.
svs2@pitt.edu
412-623-3262
Van Houten, Ben
Professor
Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
vanhoutenb@upmc.edu
412-623-7762
Wang, Lei
Research Instructor
lew72@pitt.edu
412-419-8438
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Zhang, Cheng
Associate Professor
Structural basis for G protein-coupled receptor (GPCR) signaling; development of GPCR antibodies through protein engineering.
chengzh@pitt.edu
412-383-8044
Endocrine Pharmacology/Physiology
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
de Groat, William
Distinguished Professor
Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms.
wcd2@pitt.edu
412-648-9357
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Pascal, Laura
Research Assistant Professor
lep44@pitt.edu
412-383-9564
Hormone Pharmacology
Faculty
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Oesterreich, Steffi
Professor, The Shear Family Foundation Chair in Breast Cancer Research
Molecular mechanism and clinical relevance of endocrine response in breast cancer
oesterreichs@upmc.edu
412-641-8555
Tofovic, Stevan
Associate Professor
tofovic@pitt.edu
412-648-3363
Wang, Lei
Research Instructor
lew72@pitt.edu
412-419-8438
Hormone Signaling and Action
Faculty
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Lee, Adrian
Professor; Pittsburgh Foundation Chair in Precision Medicine
leeav@upmc.edu
412-641-7557
Pascal, Laura
Research Assistant Professor
lep44@pitt.edu
412-383-9564
Pena, Karina
Research Instructor
kapena@pitt.edu
412-383-8831
Wang, Lei
Research Instructor
lew72@pitt.edu
412-419-8438
Metabolic Syndrome Pharmacology
Faculty
Chang, Fei
Research Instructor
fec29@pitt.edu
530-219-1806
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Jackson, Edwin
Distinguished Professor
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites.
edj@pitt.edu
412-648-1505
Palladino, Michael
Professor & Vice Chair for Faculty Affairs
Combined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions
mjp44@pitt.edu
412-383-5900
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Tofovic, Stevan
Associate Professor
tofovic@pitt.edu
412-648-3363
Neuropharmacology
The physiological basis of neuronal toxicity caused by various insults including excitatory amino acids, oxidative stress and cerebral ischemia is being studied using quantitative imaging techniques, confocal microscopy, genetic approaches in model organisms, and molecular approaches in cultured cell lines, cultured primary neurons and in intact animals. These studies aim to develop an understanding of the mechanisms of neuronal injury in acute and chronic disorders. The regulation of the expression of voltage-gated ion channels in cell lines and primary cultures is being studied by molecular and patchclamping techniques. In addition, molecular genetic, electrophysiological and cell biological approaches are being used to explore the relationships between neurotransmitter transporter structure, substrate transport, inhibitor binding and ion permeation. New quantitative imaging approaches are being used to study the basic processes of neuropeptide secretion. Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic regulation and synaptic transmission of the urogenital system. These studies include neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs. Targeted disruption of GABA receptors is being used as a tool to investigate the function of these receptors and their specific components in transgenic mice. The mechanism of action of anesthetics is being studied in genetic model organisms and using techniques of magnetic resonance spectroscopy.
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
de Groat, William
Distinguished Professor
Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms.
wcd2@pitt.edu
412-648-9357
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Fazzari, Marco
Research Assistant Professor
maf167@pitt.edu
412-626-2924
Jackson, Edwin
Distinguished Professor
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites.
edj@pitt.edu
412-648-1505
Jacob, Tija
Associate Professor & Vice Chair for Graduate Education
GABA A receptor neuropharmacology and synapses, inhibition, neurodevelopment, mental health disorders.
tcj11@pitt.edu
412-648-8136
Levitan, Edwin
Professor & Vice Chair for Research Operations
Neurotransmission, channels and signaling.
elevitan@pitt.edu
412-648-9486
Palladino, Michael
Professor & Vice Chair for Faculty Affairs
Combined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions
mjp44@pitt.edu
412-383-5900
Pharmacology of Cell and Organ Systems
Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic synaptic transmission and the autonomic regulation of the urogenital and renal systems. These studies include: 1) neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs; 2) biochemical/molecular analysis of the role of PP-fold peptides released from autonomic synaptic junctions in the regulation of renovascular tone and arterial blood pressure in genetic hypertension; and 3) the interaction between the sympathetic nervous system and estradiol on renal function.
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
Bisello, Alessandro
Professor & Vice Chair for Experiential Learning
Structure, signaling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function.
alb138@pitt.edu
412-648-7347
Chang, Fei
Research Instructor
fec29@pitt.edu
530-219-1806
Cifuentes Pagano, Eugenia
Research Assistant Professor
mec110@pitt.edu
412-648-2610
de Groat, William
Distinguished Professor
Study of the autonomic mechanisms involved in the control of urogenital function. Study of visceral pain mechanisms.
wcd2@pitt.edu
412-648-9357
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Jackson, Edwin
Distinguished Professor
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites.
edj@pitt.edu
412-648-1505
Lancaster, Jack
Professor
doctorno@pitt.edu
412-383-8012
Lee, Adrian
Professor; Pittsburgh Foundation Chair in Precision Medicine
leeav@upmc.edu
412-641-7557
Mamonova, Tatyana
Research Assistant Professor
tbm7@pitt.edu
412-383-8838
Neumann, Carola
Associate Professor & Vice Chair for Precision and Translational Pharmacology
can44@pitt.edu
412-641-7725
Oesterreich, Steffi
Professor, The Shear Family Foundation Chair in Breast Cancer Research
Molecular mechanism and clinical relevance of endocrine response in breast cancer
oesterreichs@upmc.edu
412-641-8555
Pagano, Patrick
Professor
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
pagano@pitt.edu
412-383-6505
Palladino, Michael
Professor & Vice Chair for Faculty Affairs
Combined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions
mjp44@pitt.edu
412-383-5900
Pena, Karina
Research Instructor
kapena@pitt.edu
412-383-8831
Romero, Guillermo
Associate Professor
Regulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases.
ggr@pitt.edu
412-648-9408
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Shiva, Sruti
Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine Institute
The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
sss43@pitt.edu
412-383-5854
Stabile, Laura
Research Associate Professor
stabilela@upmc.edu
412-623-2015
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Trebak, Mohamed
Professor
trebakm@pitt.edu
412-648-1381
Van Houten, Ben
Professor
Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
vanhoutenb@upmc.edu
412-623-7762
Vilardaga, Jean-Pierre
Professor
Understanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking.
jpv@pitt.edu
412-648-2055
Volonte, Daniela
Research Assistant Professor
dav18@pitt.edu
412-624-1006
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Protein Kinases & Phosphatases
Faculty
Aird, Katherine
Associate Professor
kaa140@pitt.edu
412-623-7709
Jiang, Yu
Professor
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
yuj5@pitt.edu
412-648-3390
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Pulmonary Pharmacology
Faculty
Tofovic, Stevan
Associate Professor
tofovic@pitt.edu
412-648-3363
Purine Pharmacology
Faculty
Aird, Katherine
Associate Professor
kaa140@pitt.edu
412-623-7709
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
Buj-Gomez, Raquel
Research Assistant Professor
rbg19@pitt.edu
412-623-3241
Jackson, Edwin
Distinguished Professor
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin system and estradiol metabolites.
edj@pitt.edu
412-648-1505
Receptor Pharmacology
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Huang, Yi
Assistant Professor
yih26@pitt.edu
412-641-3589
Jacob, Tija
Associate Professor & Vice Chair for Graduate Education
GABA A receptor neuropharmacology and synapses, inhibition, neurodevelopment, mental health disorders.
tcj11@pitt.edu
412-648-8136
Mamonova, Tatyana
Research Assistant Professor
tbm7@pitt.edu
412-383-8838
Pena, Karina
Research Instructor
kapena@pitt.edu
412-383-8831
Romero, Guillermo
Associate Professor
Regulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases.
ggr@pitt.edu
412-648-9408
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Trebak, Mohamed
Professor
trebakm@pitt.edu
412-648-1381
Vilardaga, Jean-Pierre
Professor
Understanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking.
jpv@pitt.edu
412-648-2055
Wang, Lei
Research Instructor
lew72@pitt.edu
412-419-8438
Zhang, Cheng
Associate Professor
Structural basis for G protein-coupled receptor (GPCR) signaling; development of GPCR antibodies through protein engineering.
chengzh@pitt.edu
412-383-8044
Redox Pharmacology
Faculty
Buj-Gomez, Raquel
Research Assistant Professor
rbg19@pitt.edu
412-623-3241
Chang, Fei
Research Instructor
fec29@pitt.edu
530-219-1806
Cifuentes Pagano, Eugenia
Research Assistant Professor
mec110@pitt.edu
412-648-2610
Fazzari, Marco
Research Assistant Professor
maf167@pitt.edu
412-626-2924
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Galbiati, Ferruccio
Professor & Vice Chair for Research
Signal transduction mechanisms in muscular dystrophy and ageing/cancer.
feg5@pitt.edu
412-648-2047
Gelhaus, Stacy
Associate Professor; Scientific Director, Health Sciences Mass Spectrometry Core
gstacy@pitt.edu
412-648-1351
Hahm, Eun-Ryeong
Research Instructor
euh2@pitt.edu
412-623-3262
Khoo, Nicholas
Research Assistant Professor
nkhoo@pitt.edu
412-648-9671
Lancaster, Jack
Professor
doctorno@pitt.edu
412-383-8012
Neumann, Carola
Associate Professor & Vice Chair for Precision and Translational Pharmacology
can44@pitt.edu
412-641-7725
Pagano, Patrick
Professor
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
pagano@pitt.edu
412-383-6505
Palladino, Michael
Professor & Vice Chair for Faculty Affairs
Combined molecular and genetic approaches to identify key proteins required for neural maintenance with age and understand the role of these gene products in metabolic disease conditions
mjp44@pitt.edu
412-383-5900
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Shiva, Sruti
Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine Institute
The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
sss43@pitt.edu
412-383-5854
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Van Houten, Ben
Professor
Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
vanhoutenb@upmc.edu
412-623-7762
Signal Transduction
The department is rich in research devoted to the analysis of signal transduction pathways and their role in normal physiological processes and disease. These include studies into the basic mechanisms of signaling by oxidizing and free radical inflammatory mediators, nitric oxide, steroids, parathyroid hormone, neurotransmitters, hypothalamic hormones, and rhodopsin. Various cell biological, forward and reverse genetic, molecular biological and biophysical approaches are used to dissect the molecular mechanisms utilized by intracellular mediators of signal transduction including cell surface receptors, nuclear receptors, caveolin, protein kinases, protein phosphatases and lipid kinases.
Faculty
Aird, Katherine
Associate Professor
kaa140@pitt.edu
412-623-7709
Altschuler, Daniel
Associate Professor
G-protein signaling mechanisms in mitogenesis and oncogenesis
altschul@pitt.edu
412.648.9751
Bisello, Alessandro
Professor & Vice Chair for Experiential Learning
Structure, signaling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function.
alb138@pitt.edu
412-648-7347
Buj-Gomez, Raquel
Research Assistant Professor
rbg19@pitt.edu
412-623-3241
DeFranco, Donald
Professor & Vice Chair for Medical Education, Associate Dean for Medical Student Research
Glucocorticoids and Neurodevelopment. Prostate cancer.
dod1@pitt.edu
412-624-4259
Fazzari, Marco
Research Assistant Professor
maf167@pitt.edu
412-626-2924
Freeman, Bruce
Irwin Fridovich Distinguished Professor and Chair
Cell Signaling; Redox Reactions
freerad@pitt.edu
412-648-9319
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Galbiati, Ferruccio
Professor & Vice Chair for Research
Signal transduction mechanisms in muscular dystrophy and ageing/cancer.
feg5@pitt.edu
412-648-2047
Gelhaus, Stacy
Associate Professor; Scientific Director, Health Sciences Mass Spectrometry Core
gstacy@pitt.edu
412-648-1351
Jacob, Tija
Associate Professor & Vice Chair for Graduate Education
GABA A receptor neuropharmacology and synapses, inhibition, neurodevelopment, mental health disorders.
tcj11@pitt.edu
412-648-8136
Jiang, Yu
Professor
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
yuj5@pitt.edu
412-648-3390
Lancaster, Jack
Professor
doctorno@pitt.edu
412-383-8012
Levitan, Edwin
Professor & Vice Chair for Research Operations
Neurotransmission, channels and signaling.
elevitan@pitt.edu
412-648-9486
Neumann, Carola
Associate Professor & Vice Chair for Precision and Translational Pharmacology
can44@pitt.edu
412-641-7725
Pagano, Patrick
Professor
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
pagano@pitt.edu
412-383-6505
Pena, Karina
Research Instructor
kapena@pitt.edu
412-383-8831
Schopfer, Francisco
Associate Professor & Vice Chair for Biotechnology Development
fjs2@pitt.edu
412-648-0193
Sharrow, Allison
Research Assistant Professor
AllisonSharrow@pitt.edu
Shiva, Sruti
Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine Institute
The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
sss43@pitt.edu
412-383-5854
Singh, Shivendra
Professor and UPMC Chair in Cancer Prevention Research
The Singh laboratory focuses on preclinical and clinical investigations of novel agents derived from dietary (eg, broccoli) and medicinal plants (eg, Withania somnifera) for chemoprevention of cancers.
svs2@pitt.edu
412-623-3262
Stabile, Laura
Research Associate Professor
stabilela@upmc.edu
412-623-2015
Straub, Adam
Associate Professor & Vice Chair, Research; Assistant Dean of Basic Sciences Faculty Affairs
Redox signaling mechanisms in the microcirculation.
astraub@pitt.edu
412-648-7097
Trebak, Mohamed
Professor
trebakm@pitt.edu
412-648-1381
Vilardaga, Jean-Pierre
Professor
Understanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking.
jpv@pitt.edu
412-648-2055
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Zhang, Cheng
Associate Professor
Structural basis for G protein-coupled receptor (GPCR) signaling; development of GPCR antibodies through protein engineering.
chengzh@pitt.edu
412-383-8044
Structural Pharmacology
Faculty
Arjunan, Palaniappa
Research Instructor
arjun@pitt.edu
412-688-6000
Bulgari, Dinara
Research Assistant Professor
dms31@pitt.edu
412-648-8693
Friedman, Peter
Professor
Parathyroid hormone receptor trafficking, regulation, signaling.
paf10@pitt.edu
412-383-7783
Furey, William
Professor
fureyw@pitt.edu
412-607-3106
Shiva, Sruti
Professor & Vice Chair for Academics and Equity Associate Director, Vascular Medicine Institute
The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
sss43@pitt.edu
412-383-5854
Vilardaga, Jean-Pierre
Professor
Understanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking.
jpv@pitt.edu
412-648-2055
Wang, Lei
Research Instructor
lew72@pitt.edu
412-419-8438
Wang, Qiming Jane
Professor
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
qjw1@pitt.edu
412-383-7754
Zhang, Cheng
Associate Professor
Structural basis for G protein-coupled receptor (GPCR) signaling; development of GPCR antibodies through protein engineering.
chengzh@pitt.edu
412-383-8044
Systems Biology of Cancer
Faculty
Galbiati, Ferruccio
Professor & Vice Chair for Research
Signal transduction mechanisms in muscular dystrophy and ageing/cancer.
feg5@pitt.edu
412-648-2047
Lee, Adrian
Professor; Pittsburgh Foundation Chair in Precision Medicine
leeav@upmc.edu
412-641-7557
Systems Pharmacology
Faculty
Beckel, Jonathan
Associate Professor
Molecular, cellular and physiological approaches to understand epithelial-afferent nerve interactions and how changes in this communication play a role in bladder pathology
jmbeckel@pitt.edu
412-383-5004
Vilardaga, Jean-Pierre
Professor
Understanding molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking.
jpv@pitt.edu
412-648-2055