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"Metabolic Regulation of Quiescence in Ovarian Can...
Pharmacology & Chemical Biology Seminar Series
4/20/2023 - 12:00 PM-1:00 PM
"Metabolic Regulation of Quiescence in Ovarian Cancer"
Allison Sharrow, PhD
Research Assistant Professor
University of Pittsburgh
The overall goal of my work is to gain a better understanding of chemoresistance in ovarian cancer. Quiescent cells are better able to resist chemotherapy treatment compared to their proliferative counterparts. Quiescent cells have long been thought to be metabolically inactive. However, we and others have found that they are metabolically active but favor fatty acid metabolism. My current project seeks to understand how the fatty acid metabolic intermediate acetyl-CoA regulates quiescence in ovarian cancer. A better understanding of this pathway has the potential to identify novel therapeutic approaches to overcome ovarian cancer chemoresistance.
Thomas E. Starzl Biomedical Science Tower
1395 Conference Room
203 Lothrop St
Pittsburgh, PA 15213
Contact
Melanie Hoffner